Proyecto eMadrid: metodologías educativas, ludificación y calidad

Esta comunicación presenta un conjunto de trabajos de investigación sobre metodologías docentes, ludificación y calidad realizados en el seno del proyecto eMadrid, de la Comunidad Autónoma de Madrid. En primer lugar se resumen los trabajos realizados en los dos primeros años del proyecto. Posteriormente se presentan las líneas de trabajo previstas para los dos años restantesEstos trabajos se han financiado parcialmente por el proyecto eMadrid (S2013/ICE-2715) de la Comunidad de Madrid, los proyectos FLEXOR (TIN2014-52129-R), RESET (TIN2014-53199-C3-1-R) e iProg (TIN2015-66731-C2-1-R) del Ministerio de Economía y Competitividad, y el proyecto “Adaptación de la metodología PhyMEL a la formación clínica mediante el uso de simuladores” financiado por la empresa Medical Simulato

Analysis of the bearing capacity of unbound granular mixtures with rubber particles from scrap tyres when used as sub-ballast

[EN] Scrap tyres are a problematic waste material. As a method for recycling large quantities of rubber from scrap tyres, this paper analyses the use of unbound granular mixtures with varying percentages of rubber particles as sub-ballast in railway lines. Bearing capacity for such mixtures is studied in laboratory and field tests using static and dynamic plate load tests, as well as cyclic triaxial tests. It is found that adding rubber increases permanent and resilient strain and that none of the mixtures suffer plastic creep after 2.5 million cycles. Considering the usual bearing capacity requirements, the optimum rubber content is 2.5% (by weight). This percentage increases resistance to degradation while ensuring sufficient bearing capacity.Hidalgo Signes, C.; Martínez Fernández, P.; Garzón-Roca, J.; Insa Franco, R. (2016). Analysis of the bearing capacity of unbound granular mixtures with rubber particles from scrap tyres when used as sub-ballast. Materiales de Construcción. 66(324):1-15. doi:10.3989/mc.2016.11515S11566324Humphrey, D., & Blumenthal, M. (2010). The Use of Tire-Derived Aggregate in Road Construction Applications. Green Streets and Highways 2010. doi:10.1061/41148(389)25Wolfe, S. L., Humphrey, D. N., & Wetzel, E. A. (2004). Development of Tire Shred Underlayment to Reduce Groundborne Vibration from LRT Track. Geotechnical Engineering for Transportation Projects. doi:10.1061/40744(154)62Salgado, R., Yoon, S., & Siddiki, N. (2003). Construction of Tire Shreds Test Embankment. doi:10.5703/1288284313165Yoon, S., Prezzi, M., Siddiki, N. Z., & Kim, B. (2006). Construction of a test embankment using a sand–tire shred mixture as fill material. Waste Management, 26(9), 1033-1044. doi:10.1016/j.wasman.2005.10.009Sol-Sánchez, M., Thom, N. H., Moreno-Navarro, F., Rubio-Gámez, M. C., & Airey, G. D. (2015). A study into the use of crumb rubber in railway ballast. Construction and Building Materials, 75, 19-24. doi:10.1016/j.conbuildmat.2014.10.045Hidalgo Signes, C., Martínez Fernández, P., Medel Perallón, E., & Insa Franco, R. (2014). Characterisation of an unbound granular mixture with waste tyre rubber for subballast layers. Materials and Structures, 48(12), 3847-3861. doi:10.1617/s11527-014-0443-z8. PF-7 (2006) Pliego de Prescripciones Técnicas Generales de Materiales Ferroviarios PF-7: Subbalasto (General Technical Specifications for Railway Materials PF-7: Sub-ballast). Spanish Ministry of Public Works and Transport, Madrid. (In Spanish).10. Panadero, C.; Sanz, J.L. (2010) Análisis de las propiedades del sub-balasto: Contradicciones y procesos que afectan a su función (Analysis of sub-ballast properties: Contradictions and processes that affect their performance). Revista Ingeopres 196, 14–21. (In Spanish).12. Santiago, E.; García, J.L.; González, P. (2010) Comparación de diferentes métodos de control de compactación del subbalasto (Comparison of different sub-ballast compaction control methods). CEDEX Geotechnical Laboratory, Madrid. (In Spanish).Tompai, Z. (2008). Conversion between static and dynamic load bearing capacity moduli and introduction of dynamic target values. Periodica Polytechnica Civil Engineering, 52(2), 97. doi:10.3311/pp.ci.2008-2.0617. Melis, M. (2006). Terraplenes y Balasto en Alta Velocidad Ferroviaria (Embankment and ballast in high speed railways). Revista de Obras Públicas 3464, 7–36. (In Spanish).Werkmeister, S., Dawson, A. R., & Wellner, F. (2005). Permanent Deformation Behaviour of Granular Materials. Road Materials and Pavement Design, 6(1), 31-51. doi:10.1080/14680629.2005.9689998Cerni, G., Cardone, F., Virgili, A., & Camilli, S. (2012). Characterisation of permanent deformation behaviour of unbound granular materials under repeated triaxial loading. Construction and Building Materials, 28(1), 79-87. doi:10.1016/j.conbuildmat.2011.07.066Speir, R., & Witczak, M. (1996). Use of Shredded Rubber in Unbound Granular Flexible Pavement Layers. Transportation Research Record: Journal of the Transportation Research Board, 1547, 96-106. doi:10.3141/1547-1424. Santamarina, J.C.; Klein, K.A.; Fam, M.A. (2001) Soils and Waves. Particulate Materials. Behavior, Characterization and Process Monitoring. John Wiley & Sons Ltd., Baffins Lane, Chichester.25. Pe-a, M. (2003) Tramos de ensayo de vía en placa en la línea del corredor del Mediterráneo para su explotación a alta velocidad (Slab track test sites in the Mediterranean Corridor for high speed use). Revista de Obras Públicas 3431, 57–68. (In Spanish).Cecich, V., Gonzales, L., Hoisaeter, A., Williams, J., & Reddy, K. (1996). Use of Shredded Tires as Lightweight Backfill Material for Retaining Structures. Waste Management & Research, 14(5), 433-451. doi:10.1177/0734242x960140050

Effect of climate on the epidemiology of bovine hypodermosis in algeria

In order to explore the effect of climate on cattle warble fly infestation, a total of 1.635 animals from 4 departments of Northern Algeria were examined visually and by manual palpation for the presence of warbles. Cattle were examined from March to June 2014, coinciding with the peak of emergence of warbles, and both the prevalence and intensity of infestation were recorded. The departments included in this study were located in the two different climatic areas in Northern Algeria: humid (Bejaia and Tizi Ouzou) and semi-arid (Tissemssilt and Ain Defla). The overall prevalence was 28.75%; the intensity of infestation ranged from 1 to 98 warbles per animal (mean 18.93±11.05). The prevalence and intensity of infestation within the departments with semi-arid climate (38.23%; 21.57±11.98) was significantly higher than in those with humid climate (20.74%; 14.84±7.86). The CHAID algorithm showed the climate as the most influencing factor for warble fly prevalence, followed by the husbandry system and breed. Logistic regression and multivariate ANOVA indicate that in addition to climate, other intrinsic (age, breed) and extrinsic factors (husbandry system, treatment) included in the study also were associated with both, prevalence and intensity of infestation. Our results indicate that in semiarid areas of Northern Algeria environmental conditions are more favorable for the development of free stages (pupae and adult flies) of Hypoderma spp life-cycle than in humid areas

Clasificación microscópica de las lesiones cutáneas producidas por Hypoderma lineatum

Trabajo presentado a la: XXVII Reunión de la Sociedad Española de Anatomía Patológica Veterinaria. (Barcelona, España, 17 al 19 Junio, 2015).Peer Reviewe

Overview of recent TJ-II stellarator results

The main results obtained in the TJ-II stellarator in the last two years are reported. The most important topics investigated have been modelling and validation of impurity transport, validation of gyrokinetic simulations, turbulence characterisation, effect of magnetic configuration on transport, fuelling with pellet injection, fast particles and liquid metal plasma facing components. As regards impurity transport research, a number of working lines exploring several recently discovered effects have been developed: the effect of tangential drifts on stellarator neoclassical transport, the impurity flux driven by electric fields tangent to magnetic surfaces and attempts of experimental validation with Doppler reflectometry of the variation of the radial electric field on the flux surface. Concerning gyrokinetic simulations, two validation activities have been performed, the comparison with measurements of zonal flow relaxation in pellet-induced fast transients and the comparison with experimental poloidal variation of fluctuations amplitude. The impact of radial electric fields on turbulence spreading in the edge and scrape-off layer has been also experimentally characterized using a 2D Langmuir probe array. Another remarkable piece of work has been the investigation of the radial propagation of small temperature perturbations using transfer entropy. Research on the physics and modelling of plasma core fuelling with pellet and tracer-encapsulated solid-pellet injection has produced also relevant results. Neutral beam injection driven Alfvénic activity and its possible control by electron cyclotron current drive has been examined as well in TJ-II. Finally, recent results on alternative plasma facing components based on liquid metals are also presented. ISSN:0029-5515 ISSN:1741-432

Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

19 Páginas.-- 7 FigurasATP-citrate lyase is a central integrator of cellular metabolism in the interface of protein, carbohydrate, and lipid metabolism. The physiological consequences as well as the molecular mechanisms orchestrating the response to long-term pharmacologically induced Acly inhibition are unknown. We report here that the Acly inhibitor SB-204990 improves metabolic health and physical strength in wild-type mice when fed with a high-fat diet, while in mice fed with healthy diet results in metabolic imbalance and moderated insulin resistance. By applying a multiomic approach using untargeted metabolomics, transcriptomics, and proteomics, we determined that, in vivo, SB-204990 plays a role in the regulation of molecular mechanisms associated with aging, such as energy metabolism, mitochondrial function, mTOR signaling, and folate cycle, while global alterations on histone acetylation are absent. Our findings indicate a mechanism for regulating molecular pathways of aging that prevents the development of metabolic abnormalities associated with unhealthy dieting. This strategy might be explored for devising therapeutic approaches to prevent metabolic diseases.This work was funded by grants from the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, co-funded by Fondos FEDER (PI15/00134, PI18/01590, CPII19/00023 to A.M.M.) and the Ministerio de Ciencia e Innovación (PID2021-123965OB-100 to A.M.M.). A.M.M. is funded by the Junta de Andalucía P20_00480, the Spanish Society of Diabetes, and CSIC 202220I059. M.S.K. is funded by the Nordea Foundation (#02-2017-1749), the Novo Nordisk Foundation (#NNF17OC0027812), the Neye Foundation, the Lundbeck Foundation (#R324-2019-1492), the Ministry of Higher Education and Science of Denmark (#0238-00003B). V.C.G. is funded by the Instituto de Salud Carlos III (CP19/00046), co-funded by FEDER. F.M. is funded by the CIBERDEM of the Instituto de Salud Carlos III. A.M.M. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. We acknowledge the support of the group of basic research on diabetes of the Spanish Society of Diabetes.Peer reviewe

Overview of recent TJ-II stellarator results

The main results obtained in the TJ-II stellarator in the last two years are reported. The most important topics investigated have been modelling and validation of impurity transport, validation of gyrokinetic simulations, turbulence characterisation, effect of magnetic configuration on transport, fuelling with pellet injection, fast particles and liquid metal plasma facing components. As regards impurity transport research, a number of working lines exploring several recently discovered effects have been developed: the effect of tangential drifts on stellarator neoclassical transport, the impurity flux driven by electric fields tangent to magnetic surfaces and attempts of experimental validation with Doppler reflectometry of the variation of the radial electric field on the flux surface. Concerning gyrokinetic simulations, two validation activities have been performed, the comparison with measurements of zonal flow relaxation in pellet-induced fast transients and the comparison with experimental poloidal variation of fluctuations amplitude. The impact of radial electric fields on turbulence spreading in the edge and scrape-off layer has been also experimentally characterized using a 2D Langmuir probe array. Another remarkable piece of work has been the investigation of the radial propagation of small temperature perturbations using transfer entropy. Research on the physics and modelling of plasma core fuelling with pellet and tracer-encapsulated solid-pellet injection has produced also relevant results. Neutral beam injection driven Alfvénic activity and its possible control by electron cyclotron current drive has been examined as well in TJ-II. Finally, recent results on alternative plasma facing components based on liquid metals are also presentedThis work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under Grant Agreement No. 633053. It has been partially funded by the Ministerio de Ciencia, Inovación y Universidades of Spain under projects ENE2013-48109-P, ENE2015-70142-P and FIS2017-88892-P. It has also received funds from the Spanish Government via mobility grant PRX17/00425. The authors thankfully acknowledge the computer resources at MareNostrum and the technical support provided by the Barcelona S.C. It has been supported as well by The Science and Technology Center in Ukraine (STCU), Project P-507F

Tratamiento del dolor neuropático por desaferentización mediante lesión DREZ, resultados a largo plazo

Resumen: Introducción: El dolor por desaferentización secundario a lesiones medulares, avulsión del plexo braquial y otras lesiones de nervios periféricos, es a menudo refractario a tratamientos convencionales. Este trabajo evalúa la eficacia a largo plazo de la cirugía de lesión DREZ (Dorsal Root Entry Zone) en diversos síndromes de dolor neuropático por desaferentización. Pacientes y métodos: Se presenta una serie de 18 pacientes con dolor refractario por desaferentización tratados mediante lesión DREZ con radiofrecuencia. La eficacia inmediata y a largo plazo se valoró mediante la escala visual analógica (EVA) preoperatoria y postoperatoria, la valoración subjetiva del paciente, la reincorporación laboral y la reducción de la medicación analgésica. Resultados: El dolor en la EVA disminuyó significativamente de 8,6 antes de la cirugía a 2,9 de media al alta (p < 0,001). A largo plazo, con un seguimiento medio de 28 meses (6-108), el dolor se mantuvo en 4,7 en la EVA (p < 0,002). El porcentaje de pacientes con un alivio moderado a excelente del dolor fue de 77% al alta y 68% a largo plazo. El 67% de los pacientes redujo la medicación analgésica y el 28% se reincorporó al trabajo. Los mejores resultados se obtuvieron en los pacientes con avulsión del plexo braquial con una mejoría significativa del dolor a largo plazo en todos los casos. Conclusiones: La lesión DREZ por radiofrecuencia es un tratamiento eficaz y seguro para el dolor neuropático refractario por desaferentización. Abstract: Introduction: Deafferentation pain secondary to spinal cord injury, brachial plexus avulsion and other peripheral nerve injuries is often refractory to conventional treatments. This study evaluates the long-term efficacy of spinal DREZ (Dorsal Root Entry Zone) lesions for the treatment of neuropathic pain syndromes caused by deafferentation. Patients and methods: A series of 18 patients with refractory deafferentation pain treated with radiofrequency DREZ lesions is presented. The immediate and long-term efficacy was measured with the Visual Analogue Scale (VAS) before and after treatment, the patient's subjective evaluation, the percentage of patients returning to work and the reduction in pain medication. Results: Pain on the VAS significantly decreased from 8.6 preoperatively to 2.9 (p < .001) at discharge. Over the long-term, with a mean follow-up of 28 months (6-108) pain remained at 4.7 on the VAS (p < 0.002). The percentage of patients with moderate to excellent pain relief was 77% at discharge and 68% at the last follow-up. Pain medication was reduced in 67% of the patients and 28% returned to work. The best results were obtained in patients with brachial plexus avulsion, with a significant long-term pain relief in all cases. Conclusions: Radiofrequency DREZ lesion is an effective and safe treatment for refractory neuropathic pain caused by deafferentation. Palabras clave: Avulsión plexo braquial, Desaferentización, Dorsal root entry zone, Dolor, Lesión medular, Keywords: Brachial plexus avulsion, Deafferentation, Dorsal root entry zone, Pain, Spinal injur